I have been experimenting now for some time with HTML/JavaScript and Ajax style communications with the Suneido server. It has been interesting, but mostly frustrating. Working in multiple languages, multiple IDE’s, dealing with one-page web application issues, very complex. From a user perspective I think the one-page web application is very limited. Dealing with a small space leads to a lot of compromises, leading away from the traditional application behavior that users are used to. Not a good direction I think.
Next thing to explore? I think I will give wxWidgets a shot. I used it with Python before (wxPython), and it seems a good platform independent GUI environment.